NewsWise highlighted Foundation-funded Scientific Development Awardee Ajay Tambralli, MD, and his research on the immunometabolism of neutrophils in lupus and antiphospholipid syndrome (APS).
Neutrophils, crucial white blood cells, capture germs using sticky, spider web-like structures called neutrophil extracellular traps or NETs. Excessive NET formation is linked to exuberant inflammation and complications like blood clots, strokes and miscarriages.
Dr. Tambralli and his team at the University of Michigan are investigating how modifying neutrophil metabolism—specifically glycolysis and the pentose phosphate pathway—can reduce NET production and enhance APS treatment. Their research suggests that targeting these metabolic pathways could lead to more effective and safer treatments compared to current blood thinners.
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